科研团队 | Research Team

Ying XU (徐璎), Professor

研究组长

Professor, Director of CAM-SU Genomic Resource Center, Soochow University,2014-2023

Professor, Model Animal Research Center, Nanjing University,2006-2014

Postdoctoral Fellow, University of California, San Francisco, 2003-2006

Chief Scientist, PhoenixBio Co., Ltd., 2001-2003

Ph.D., Cell Biology, University of Tokyo, 1997-2001

M.D., Pathology, Saitama Medical University, 1994-1997

Lecturer, Suzhou Medical College, 1988-1994

Master, Diagnostic Radiography, Suzhou Medical College, 1985-1988

B.S., Pharmacology, Shanghai Medical University, 1980-1985

Email: yingxu@suda.edu.cn

Research interests

All tissues and organs operate with circadian rhythms, networks exhibit time-dependent traits, and diseases evolve or heal with time-dependent alterations. It is challenging to elucidate the function of circadian clock in this complex system. Our lab is combining a number of cross-cutting approaches to try to clarify the function of the circadian clock in stress or diseases.

Selected Publications

 

 

yang An Graduate
Email: anyang88@gmail.com
Junjie Deng Graduate
Email: 496741306@qq.com
Qiaocheng Zhai Graduate
Email: zhaiqiaocheng@qq.com

Kai Huang Graduate
Email: 454648181@qq.com
Zhengyun Huang Graduate
Email: 2865338849@qq.com
Chao Li Graduate
Email: 472609914@qq.com
Hui tao Postdoctoral researcher
Email: shirley4681@sina.com
Pancheng Xie Graduate
Email: pancheng122@126.com
Tao Zhang Graduate
Email: zhangtaogele@163.com
   
Zhihui Zhang Graduate
Email: ncuskzhangzhihui@163.com
   

Xing L, An Y, Shi G, Yan J, Xie P, Qu Z, Zhang Z, Liu Z, Pan D, Xu Y (2017) Correlated evolution between CK1delta Protein and the Serine-rich Motif Contributes to Regulating the Mammalian Circadian Clock. The Journal of biological chemistry 292: 161-171

Zhang L, Hirano A, Hsu PK, Jones CR, Sakai N, Okuro M, McMahon T, Yamazaki M, Xu Y, Saigoh N, Saigoh K, Lin ST, Kaasik K, Nishino S, Ptacek LJ, Fu YH (2016) A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. Proceedings of the National Academy of Sciences of the United States of America 113: E1536-1544

Shi G, Xie P, Qu Z, Zhang Z, Dong Z, An Y, Xing L, Liu Z, Dong Y, Xu G, Yang L, Liu Y, Xu Y (2016) Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Cell Rep 14: 823-834

Qu Z, Zhang H, Huang M, Shi G, Liu Z, Xie P, Li H, Wang W, Xu G, Zhang Y, Yang L, Huang G, Takahashi JS, Zhang WJ, Xu Y (2016) Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms. Elife 5

Hirano A, Shi G, Jones CR, Lipzen A, Pennacchio LA, Xu Y, Hallows WC, McMahon T, Yamazaki M, Ptacek LJ, Fu YH (2016) A Cryptochrome 2 mutation yields advanced sleep phase in humans. Elife 5

Dong Z, Huang M, Liu Z, Xie P, Dong Y, Wu X, Qu Z, Shen B, Huang X, Zhang T, Li J, Liu J, Yanase T, Zhou C, Xu Y (2016) Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve. Cell death and differentiation 23: 1602-1614

Shi G, Xing L, Liu Z, Qu Z, Wu X, Dong Z, Wang X, Gao X, Huang M, Yan J, Yang L, Liu Y, Ptacek LJ, Xu Y (2013) Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock. Proceedings of the National Academy of Sciences of the United States of America 110: 4750-4755

Liu Z, Huang M, Wu X, Shi G, Xing L, Dong Z, Qu Z, Yan J, Yang L, Panda S, Xu Y (2014) PER1 phosphorylation specifies feeding rhythm in mice. Cell Rep 7: 1509-1520

Yan J, Shi G, Zhang Z, Wu X, Liu Z, Xing L, Qu Z, Dong Z, Yang L, Xu Y (2014) An intensity ratio of interlocking loops determines circadian period length. Nucleic acids research 42: 10278-10287

Shi G, Xing L, Liu Z, Qu Z, Wu X, Dong Z, Wang X, Gao X, Huang M, Yan J, Yang L, Liu Y, Ptacek LJ, Xu Y (2013) Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock. Proceedings of the National Academy of Sciences of the United States of America 110: 4750-4755

Gu X, Xing L, Shi G, Liu Z, Wang X, Qu Z, Wu X, Dong Z, Gao X, Liu G, Yang L, Xu Y (2012) The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis. Cell death and differentiation 19: 397-405

Wu X, Liu Z, Shi G, Xing L, Wang X, Gu X, Qu Z, Dong Z, Xiong J, Gao X, Zhang C, Xu Y (2011) The circadian clock influences heart performance. Journal of biological rhythms 26: 402-411

Wang X, Tang J, Xing L, Shi G, Ruan H, Gu X, Liu Z, Wu X, Gao X, Xu Y (2010) Interaction of MAGED1 with nuclear receptors affects circadian clock function. The EMBO journal 29: 1389-1400

He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder JL, Jr., Rossner MJ, Nishino S, Fu YH (2009) The transcriptional repressor DEC2 regulates sleep length in mammals. Science 325: 866-870

Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptacek LJ (2007) Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell 128: 59-70

Xu Y, Padiath QS, Shapiro RE, Jones CR, Wu SC, Saigoh N, Saigoh K, Ptacek LJ, Fu YH (2005) Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature 434: 640-644

Xu Y, Takeda S, Nakata T, Noda Y, Tanaka Y, Hirokawa N (2002) Role of KIFC3 motor protein in Golgi positioning and integration. J Cell Biol 158: 293-303

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