Fei Zhou, Ph.D., Associate Professor

Address: 703-3126, 199 Ren-ai Road, Suzhou Industrial Park

Email: fzhou@suda.edu.cn

RESEARCH INTERESTS

1) Gene editing, especially base editing for nuclear and mitochondrial DNA

2) Circadian rhythm and physiological homeostasis

PROFESSIONAL EXPERIENCE

2014.06-now: Associate Professor, CAM-SU Genomic Resource Center, Soochow University

2013.12-2014.06: Senior Research Fellow, Shanghai Center for Bioinformatics Technology

2011.07-2013.12: Senior Scientist, WuXi AppTec (Suzhou) Co. Ltd.

EDUCATION

2006.09-2011.06: PhD in Biology, Model Animal Research Center, Nanjing University

2002.09-2006.06: BS, Biotechnology, School of Life Sciences, Nanjing University

PUBLICATION

• 1) Zhang T#, Du X#, Gu Y#, Dong Y#, Zhang W, Yuan Z, Huang X, Zou C, Zhou Y, Liu Z, Tao H, Yang L, Wu G, Hogenesch JB, Zhou CJ, Zhou F* and Xu Y*. Analysis of Diurnal Variations in Heart Rate: Potential Applications for Chronobiology and Cardiovascular Medicine. Frontiers in physiology. 2022;13:835198.
• 2) Guo J#, Chen X#, Liu Z#, Sun H#, Zhou Y, Dai Y, Ma Y, He L, Qian X, Wang J, Zhang J, Zhu Y, Zhang J*, Shen B* and Zhou F*. DdCBE mediates efficient and inheritable modifications in mouse mitochondrial genome. Molecular Therapy – Nucleic Acids. 2022;27:73-80
• 3) Liu Z#, Dong Y#, Xu Y and Zhou F*. Chronotype distribution in the Chinese population. Brain Science Advances. 2020;6:81-91.
• 4) Wang X#, Liu Z#, Li G#, Dang L, Huang S, He L, Ma Y, Li C, Liu M, Yang G, Huang X, Zhou F* and Ma X*. Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation. Molecular Therapy. 2020;28:431-440
• 5) Jia K#, Lu Z#, Zhou F#, Xiong Z, Zhang R, Liu Z, Ma Y, He L, Li C, Zhu Z, Pan D* and Lian Z*. Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption. Protein & Cell. 2019;10:832-839.
• 6) Wang L#, Zhou F#, Zhang P#, Wang H, Qu Z, Jia P, Yao Z, Shen G, Li G, Zhao G, Li J, Mao Y, Xie Z, Xu W, Xu Y*, Xu Y*. Human Type H Vessels are a Sensitive Biomarker of Bone Mass. Cell Death & Disease. 2017;8, e2760
• 7) Chen W#, Xia J#, Hu P#, Zhou F#, Chen Y, Wu J, Lei W and Shen Z. Follistatin-like 1 protects cardiomyoblasts from injury induced by sodium nitroprusside through modulating Akt and Smad1/5/9 signaling. Biochemical and Biophysical Research Communications. 2016;469:418-23.
• 8) Shen B#, Shang Z#, Wang B#, Zhang L#, Zhou F#, Li T, Chu M, Jiang H, Wang Y, Qiao T, Zhang J, Sun W, Kong X, He Y*. Genetic dissection of tie pathway in mouse lymphatic maturation and valve development. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014;34:1221-1230
• 9) Zhou F#, Chang Z#, Zhang L, Hong YK, Shen B, Wang B, Zhang F, Lu G, Tvorogov D, Alitalo K, Hemmings BA, Yang Z*, He Y*. Akt/protein kinase b is required for lymphatic network formation, remodeling, and valve development. The American Journal of Pathology. 2010;177:2124-2133
• 10) Zhang L#, Zhou F#, Han W#, Shen B, Luo J, Shibuya M, He Y*. Vegfr-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Research. 2010;20:1319-1331

OTHER PUBLICATIONS:

• 11) Li Z#, Wu J#, Zhou J#, Yuan B#, Chen J, Wu W, Mo L, Qu Z, Zhou F, Dong Y, Huang K, Liu Z, Wang T, Symmes D, Gu J, Sho E, Zhang J, Chen R* and Xu Y*. A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases. mBio. 2021;12:e0254221.
• 12) Gan Y#, Zhang T#, Chen X, Cao W, Lin L, Du L, Wang Y, Zhou F, He X, He Y, Gan J, Sheng H, Sorokin L, Shi Y* and Wang Y*. Steroids Enable Mesenchymal Stromal Cells to Promote CD8(+) T Cell Proliferation Via VEGF-C. Adv Sci. 2021;8:2003712.
• 13) Ma L#, Li W#, Zhang Y#, Qi L, Zhao Q, Li N, Lu Y, Zhang L, Zhou F, Wu Y, Yu H, He Y*, Wei B* and Wang H*. FLT4/VEGFR3 activates AMPK to coordinate glycometabolic reprogramming with autophagy and inflammasome activation for bacterial elimination. Autophagy. 2021:1-16.
• 14) Zheng Y#, Li B#, Pan D#, Cao J, Zhang J, Wang X, Li X, Hou W, Bao D, Ren L, Yang J, Wang S, Qiu Y, Zhou F, Liu Z, Zhu S, Zhang L, Qing T, Wang Y, Yu Y*, Wu J*, Hu X* and Shi L*. Functional consequences of a rare missense BARD1 c.403G>A germline mutation identified in a triple-negative breast cancer patient. Breast Cancer Research. 2021;23:53.
• 15) Zhang T*, Xie P*, Dong Y*, Liu Z, Zhou F, Pan D, Huang Z, Zhai Q, Gu Y, Wu Q, Tanaka N, Obata Y, Bradley A, Lelliott CJ, Sanger Institute Mouse Genetics P, Nutter LMJ, McKerlie C, Flenniken AM, Champy MF, Sorg T, Herault Y, Angelis MH, Durner VG, Mallon AM, Brown SDM, Meehan T, Parkinson HE, Smedley D, Lloyd KCK, Yan J, Gao X, Seong JK, Wang CL, Sedlacek R, Liu Y, Rozman J, Yang L and Xu Y#. High-throughput discovery of genetic determinants of circadian misalignment. PLoS Genetics. 2020;16:e1008577.
• 16) Chu M#, Li Taot#, Shen B, Cao X, Zhong H, Zhang L, Zhou F, Ma W, Jiang H, Xie P, Liu Z, Dong N, Xu Y, Zhao Y, Xu G, Lu P, Luo J, Wu Q, Alitalo K, Koh GY, Ralf. HA and He Y*. Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII. Elife. 2016;5.
• 17) Holopainen T#, Huang H#, Chen C*, Kim KE, Zhang L, Zhou F, Han W, Li C, Yu J, Wu J, Koh GY, Alitalo K*, He Y*. Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment. Cancer Research. 2009;69:4656-4664